| ITF Women Riba-Roja De Turia | 10/07 10:00 | 44 | Despina Papamichail v Alba Carrillo Marin | 6-4,6-3 | |
| ITF Women Santa Margherita | 09/27 16:00 | 26 | [476] Despina P'michail v Deborah Chiesa [224] | 5-7,6-3,1-6 | |
| ITF Women Santa Margherita | 09/25 15:55 | 25 | Despina P'michail v Chloe Compson | 6-1,6-0 | |
| ITF Women Dobrich | 09/19 11:50 | 25 | [217] Andreea A. Rosca v Despina P'michail [443] | 3-6,6-2,7-5 | |
| ITF Women Santa Margherita | 09/12 12:00 | 25 | [414] Despina Papamichail v Jessica Pieri [217] | 5-7,4-6 | |
| ITF Women Sofia | 09/02 09:00 | 54 | Despina Papamichail v Anastasia Pribylova | 2-6,6-4,4-6 | |
| ITF Women Braunschweig | 08/23 10:00 | 26 | [334] Jesika Maleckova v Despina Papamichail [382] | 6-3,6-4 | |
| ITF Women Braunschweig | 08/21 10:00 | 25 | [382] Despina Papamichail v Georgia Brescia [271] | 6-2,7-6 | |
| ITF Women LPD Gran Canaria | 08/13 14:30 | 25 | [377] Despina Papamichail v Chloe Paquet [313] | 3-6,6-2,2-6 | |
| ITF Women LPD Gran Canaria | 08/06 17:30 | 25 | [355] Panna Udvardy v Despina Papamichail [377] | 6-1,6-1 | |
| ITF Women Darmstadt | 07/18 15:30 | 25 | [375] Despina Papamichail v Katharina Hobgarski [266] | 6-3,3-6,3-6 | |
| ITF Women Versmold Qual | 07/10 11:00 | 54 | Pemra Ozgen v Despina Papamichail | 4-6,6-1,6-3 | |
| ITF Women Versmold Qual | 07/09 15:35 | 54 | Anna Gabric v Despina Papamichail | 1-6,4-6 | |
| ITF Women Versmold Qual | 07/08 14:50 | 54 | Merel Hoedt v Despina Papamichail | 4-6,3-6 | |
| ITF Women Aschaffenburg | 07/04 11:00 | 25 | [500] Anastasia Detiuc v Despina Papamichail [357] | 6-1,6-7,6-1 | |
| ITF Women Aschaffenburg Qual | 07/02 11:00 | - | [357] Despina Papamichail v Dia Evtimova [438] | 6-1,6-3 | |
| ITF Women Aschaffenburg Qual | 07/01 12:00 | - | Despina Papamichail v Nora Niedmers | 6-2,6-2 | |
| ITF Women Bastad | 06/29 08:00 | 27 | [229] Ulrikke Eikeri v Despina Papamichail [360] | 7-5,7-5 | |
| ITF Women Bastad | 06/28 11:40 | 26 | [392] Anna Bondar v Despina Papamichail [360] | 6-4,5-7,2-6 | |
| ITF Women Bastad | 06/26 13:15 | 25 | Malene Helgo v Despina Papamichail | 1-6,6-3,6-7 | |
| ITF Women Ystad | 06/20 09:55 | 26 | [360] Despina Papamichail v Anna Danilina [459] | 4-6,6-1,1-6 | |
| ITF Women Ystad | 06/19 11:00 | 25 | Despina Papamichail v Jacqueline Cabaj Awad | 6-1,6-2 | |
| ITF Women Essen | 06/12 12:30 | 25 | Dasha Ivanova v Despina Papamichail | 0-6,6-3,7-5 | |
| ITF Women Nis | 06/02 08:00 | 28 | Despina Papamichail v Timea Jaruskova | 1-6,6-3,3-6 | |
| ITF Women Nis | 06/01 10:20 | 27 | Despina Papamichail v Gabriela Pantuckova | 7-5,6-7,6-4 | |
| ITF Women Nis | 05/31 11:30 | 26 | Despina Papamichail v Aleksandra Stosic | 6-3,6-2 | |
| ITF Women Nis | 05/30 08:00 | 25 | Despina Papamichail v Andrijana Stoilkovic | 6-0,7-5 | |
| ITF Women Caserta | 05/22 17:15 | 25 | Thaisa Grana Pedretti v Despina Papamichail | 6-2,5-7,6-2 | |
| ITF Women San Severo | 05/19 14:00 | 29 | [487] Simona Waltert v Despina Papamichail [377] | 1-6,2-6 | |
| ITF Women San Severo | 05/18 15:15 | 28 | Lucia Bronzetti v Despina Papamichail | 1-6,3-6 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.