| ITF W15 Cairo | 04/19 08:00 | 27 | Aya El Sayed v Despina Papamichail | 1-6,3-6 | |
| ITF W15 Cairo | 04/18 08:00 | 26 | Alica Rusova v Despina Papamichail | 1-6,5-7 | |
| ITF W15 Cairo | 04/17 08:00 | 25 | Jennifer Rosa Dourado v Despina Papamichail | 0-6,2-6 | |
| ITF W25 Tunis | 04/10 11:30 | 25 | [327] Jaqueline Adina Cristian v Despina Papamichail [477] | 6-4,6-1 | |
| ITF W25 Tunis | 04/09 11:25 | 54 | Despina Papamichail v Melanie Klaffner | 6-1,6-4 | |
| ITF W25 Tunis | 04/08 13:30 | 54 | Despina Papamichail v Adesuwa Osabuohien | 6-0,6-0 | |
| ITF W25 Campinas | 03/28 13:00 | 26 | [461] Despina Papamichail v Danka Kovinic [192] | 2-6,0-6 | |
| ITF W25 Campinas | 03/27 14:50 | 25 | [385] Louisa Chirico v Despina Papamichail [461] | 6-2,4-6,3-6 | |
| ITF W25 Campinas | 03/26 13:00 | 45 | [438] Irene Burillo Escorihuela v Despina Papamichail [461] | 6-7,5-7 | |
| ITF W25 Campinas | 03/25 13:00 | 45 | Mariana Galvao Borges v Despina Papamichail | 0-6,0-6 | |
| ITF W25 Curitiba | 03/18 13:00 | 45 | Despina Papamichail v Jaqueline Adina Cristian | 4-6,6-1,6-10 | |
| ITF W25 Sao Paulo | 03/12 13:00 | 45 | [350] Ana Sofia Sanchez v Despina Papamichail [460] | 6-2,6-4 | |
| ITF W25 Sao Paulo | 03/11 13:30 | 45 | Despina Papamichail v Gabriela Lee | 6-3,2-6,10-7 | |
| ITF W15 Monastir | 02/24 13:15 | 29 | [473] Mirjam Bjorklund v Despina Papamichail [458] | 1-6,7-6,6-3 | |
| ITF W15 Monastir | 02/23 09:00 | 28 | Alice Rame v Despina Papamichail | 4-6,0-6 | |
| ITF W15 Monastir | 02/22 09:00 | 27 | Natalia Orlova v Despina Papamichail | 1-6,1-6 | |
| ITF W15 Monastir | 02/21 09:00 | 26 | Kelia Le Bihan v Despina Papamichail | 0-6,3-6 | |
| ITF W15 Monastir | 02/20 11:15 | 25 | Elisabetta Cocciaretto v Despina Papamichail | 6-7,2-6 | |
| ITF W15 Monastir | 02/14 10:25 | 26 | Marta Lesniak v Despina Papamichail | 6-3,6-3 | |
| ITF W15 Monastir | 02/13 11:25 | 25 | Clara Vlasselaer v Despina Papamichail | 7-5,1-6,5-7 | |
| 2019 Fed Cup | 02/09 10:00 | 28 | [462] Despina Papamichail v Ipek Soylu [461] | 3-6,6-2,6-2 | |
| ITF W25 Plantation | 01/22 15:00 | 45 | [391] Olga Govortsova v Despina Papamichail [458] | 6-4,6-1 | |
| ITF W25 Plantation | 01/21 16:30 | 45 | Despina Papamichail v Marine Partaud | 6-1,7-6 | |
| ITF W25 Daytona Beach | 01/15 16:45 | 45 | [403] Irina Fetecau v Despina Papamichail [458] | 6-3,6-3 | |
| ITF W25 Daytona Beach | 01/14 16:00 | 45 | Stephanie Wagner v Despina Papamichail | 4-6,1-6 | |
| ITF Women Colina | 11/07 14:00 | 26 | [271] Shilin Xu v Despina P'michail [477] | 6-3,6-2 | |
| ITF Women Colina | 11/06 16:45 | 25 | [448] Nathaly Kurata v Despina P'michail [477] | 6-7,6-7 | |
| ITF Women Sant Cugat | 10/30 09:30 | 25 | [383] Marina B Ribera v Despina Papamichail [475] | 6-4,7-5 | |
| ITF Women Seville | 10/14 12:00 | 44 | Despina Papamichail v Rebeka Masarova | 1-6,4-6 | |
| ITF Women Riba-Roja De Turia | 10/08 12:55 | 44 | [479] Despina Papamichail v Lina Gjorcheska [489] | 2-6,1-6 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.