| WTA Luxembourg | 10/12 16:20 | 45 | [261] Despina Papamichail v Marta Kostyuk [163] | 4-6,3-6 | |
| ITF W25 Santa Margherita | 10/08 12:05 | 25 | Corinna Dentoni v Despina Papamichail | 3-6,6-0,6-0 | |
| ITF W60 Valencia | 09/24 09:00 | 54 | [263] Despina Papamichail v Guiomar MZD Reales [349] | 6-3,2-6,8-10 | |
| ITF W60 Valencia | 09/23 10:30 | 54 | Despina Papamichail v Jessica B Maneiro | 6-4,6-3 | |
| ITF W25 Frydek Mistek | 09/14 09:00 | 28 | Despina Papamichail v Ekaterine Gorgodze | 0-6,2-6 | |
| ITF W25 Frydek Mistek | 09/13 09:00 | 27 | [437] Vlada Koval v Despina Papamichail [276] | 5-7,6-7 | |
| ITF W25 Frydek Mistek | 09/12 09:00 | 26 | [451] Karolina Kubanova v Despina Papamichail [276] | 0-6,1-6 | |
| ITF W25 Frydek Mistek | 09/11 09:00 | 25 | Johana Markova v Despina Papamichail | 4-6,4-6 | |
| ITF W60 Zagreb | 09/07 09:30 | 27 | [282] Despina Papamichail v Reka-Luca Jani [276] | 4-6,5-7 | |
| ITF W60 Zagreb | 09/05 10:45 | 26 | [193] Martina Trevisan v Despina Papamichail [282] | 3-6,6-1,4-6 | |
| ITF W60 Zagreb | 09/04 09:00 | 25 | [282] Despina Papamichail v Maryna Zanevska [275] | 6-4,7-5 | |
| ITF W60 Zagreb | 09/02 08:00 | 54 | [282] Despina Papamichail v Yana Morderger [330] | 6-2,6-2 | |
| ITF W60 Zagreb | 09/01 08:40 | 54 | Despina Papamichail v Iva Zelic | 6-0,6-1 | |
| ITF W25 Bécs | 08/29 11:55 | 26 | [282] Despina Papamichail v Laura Ioana Paar [237] | 2-6,0-6 | |
| ITF W25 Bécs | 08/27 10:00 | 25 | [282] Despina Papamichail v Andrea Lazaro Garcia [398] | 1-6,6-2,6-2 | |
| ITF W25 LPD Gran Canaria | 08/16 10:00 | 27 | Ana Sofia Sanchez v Despina Papamichail | 4-6,6-3,6-4 | |
| ITF W25 LPD Gran Canaria | 08/15 10:00 | 26 | Ana L De La Nuez v Despina Papamichail | 2-6,2-6 | |
| ITF W25 LPD Gran Canaria | 08/14 15:00 | 25 | Maria G Carrasco v Despina Papamichail | 4-6,7-5,3-6 | |
| ITF W25 LPD Gran Canaria | 08/09 10:00 | 27 | [294] Despina Papamichail v Leonie Kung [378] | 3-6,6-7 | |
| ITF W25 LPD Gran Canaria | 08/08 09:00 | 26 | [294] Despina Papamichail v Alba Carrillo Marin [489] | 5-7,6-3,7-6 | |
| ITF W25 LPD Gran Canaria | 08/07 09:00 | 25 | Despina Papamichail v Lucia Cortez Llorca | 6-4,4-6,6-1 | |
| ITF W25 Aschaffenburg | 07/21 11:30 | 29 | [341] Jule Niemeier v Despina Papamichail [470] | 2-6,7-5,2-6 | |
| ITF W25 Aschaffenburg | 07/20 15:50 | 28 | [470] Despina Papamichail v Katharina Hobgarski [208] | 2-6,6-4,6-2 | |
| ITF W25 Aschaffenburg | 07/19 11:30 | 27 | Despina Papamichail v Ivana Popovic | 4-6,6-1,6-3 | |
| ITF W25 Aschaffenburg | 07/18 11:00 | 26 | Despina Papamichail v Indy De Vroome | 5-7,6-3,6-4 | |
| ITF W25 Aschaffenburg | 07/17 13:45 | 25 | [388] Irene Burillo Escorihuela v Despina Papamichail [470] | 6-1,4-6,0-6 | |
| ITF W25 Getxo | 07/14 08:30 | 29 | [453] Despina Papamichail v Sandra Samir [499] | 6-2,6-4 | |
| ITF W25 Getxo | 07/13 10:30 | 28 | [453] Despina Papamichail v Irene B Escorihuela [392] | 6-4,6-7,6-3 | |
| ITF W25 Getxo | 07/12 11:00 | 27 | [258] Nadia Podoroska v Despina Papamichail [453] | 0-6,4-6 | |
| ITF W25 Getxo | 07/11 09:00 | 26 | [453] Despina Papamichail v Lina Gjorcheska [372] | 7-5,6-3 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.