Stadium: James H. Hilton Coliseum
Home Manager: T.J. Otzelberger Away Manager: Matt Crenshaw
| NCAAB | 2022/03/02 01:00 | IUPUI v Oakland | L | 58-70 |
| NCAAB | 2022/02/26 21:45 | Wisc Green Bay v IUPUI | L | 67-41 |
| NCAAB | 2022/02/25 01:00 | Wisc Milwaukee v IUPUI | L | 66-54 |
| NCAAB | 2022/02/19 19:00 | IUPUI v Youngstown State | L | 61-74 |
| NCAAB | 2022/02/18 00:00 | IUPUI v Robert Morris | W | 66-56 |
| NCAAB | 2022/02/15 01:00 | IUPUI v Illinois-Chicago | L | 54-57 |
| NCAAB | 2022/02/12 20:00 | IUPUI v Cleveland State | L | 45-83 |
| NCAAB | 2022/02/11 00:00 | IUPUI v IPFW | L | 57-72 |
| NCAAB | 2022/03/26 01:59 | Iowa State v Miami Florida | L | 56-70 |
| NCAAB | 2022/03/20 22:10 | Iowa State v Wisconsin | W | 54-49 |
| NCAAB | 2022/03/18 23:57 | Iowa State v LSU | W | 59-54 |
| NCAAB | 2022/03/11 02:30 | Iowa State v Texas Tech | L | 41-72 |
| NCAAB | 2022/03/05 23:00 | Iowa State v Baylor Bears | L | 68-75 |
| NCAAB | 2022/03/03 00:00 | Oklahoma State v Iowa State | L | 53-36 |
| NCAAB | 2022/02/26 19:00 | Iowa State v Kansas State | W | 74-73 |
| NCAAB | 2022/02/24 00:00 | West Virginia v Iowa State | W | 81-84 |