Stadium: Macalester Stadium Round: 1
| NCAAF | 2022/10/29 18:00 | Hamline Pipers v Macalester Scots | W | 20-33 |
| NCAAF | 2022/10/22 18:00 | Macalester Scots v Bethel Royals | L | 13-63 |
| NCAAF | 2022/10/15 18:00 | Macalester Scots v Augsburg Auggies | L | 21-42 |
| NCAAF | 2022/10/08 18:00 | Concordia-Moorhead Cobbers v Macalester Scots | L | 36-7 |
| NCAAF | 2022/10/01 18:00 | Carleton Knights v Macalester Scots | L | 56-27 |
| NCAAF | 2022/09/25 00:00 | Macalester Scots v St Olaf Oles | L | 32-38 |
| NCAAF | 2022/09/10 23:00 | Macalester Scots v Martin Luther Knights | W | 43-7 |
| NCAAF | 2022/09/03 23:00 | Minnesota Morris Cougars v Macalester Scots | W | 24-45 |
| NCAAF | 2022/10/29 18:00 | St Scholastica Saints v St Johns Johnnies | L | 6-56 |
| NCAAF | 2022/10/22 18:00 | St Scholastica Saints v St Olaf Oles | L | 28-33 |
| NCAAF | 2022/10/15 18:00 | Carleton Knights v St Scholastica Saints | L | 56-20 |
| NCAAF | 2022/10/08 18:00 | Gustavus Adolphus Gusties v St Scholastica Saints | L | 77-7 |
| NCAAF | 2022/10/01 18:00 | St Scholastica Saints v Hamline Pipers | W | 43-42 |
| NCAAF | 2022/09/24 18:00 | Augsburg Auggies v St Scholastica Saints | L | 50-13 |
| NCAAF | 2022/09/17 18:00 | Crown Storm v St Scholastica Saints | W | 14-63 |
| NCAAF | 2022/09/03 17:00 | Sewanee Tigers v St Scholastica Saints | L | 50-0 |