Stadium: Cramton Bowl Round: 1
Home Manager: Rich Rodriguez Away Manager: Colby Carthel
| NCAAF | 2021/11/27 20:00 | Stephen F. Austin v Incarnate Word | L | 28-35 |
| NCAAF | 2021/11/20 22:00 | Stephen F. Austin v Lamar | W | 42-6 |
| NCAAF | 2021/11/13 22:00 | Stephen F. Austin v Central Arkansas | W | 27-14 |
| NCAAF | 2021/11/06 21:00 | Eastern Kentucky v Stephen F. Austin | W | 17-31 |
| NCAAF | 2021/10/30 21:00 | Abilene Christian v Stephen F. Austin | W | 27-41 |
| NCAAF | 2021/10/24 01:00 | Stephen F. Austin v Utah Tech | W | 37-20 |
| NCAAF | 2021/10/09 20:00 | Stephen F. Austin v Jacksonville State | L | 24-28 |
| NCAAF | 2021/10/02 21:00 | Sam Houston State v Stephen F. Austin | L | 21-20 |
| NCAAF | 2021/11/20 19:00 | Jacksonville State v Eastern Kentucky | L | 31-39 |
| NCAAF | 2021/11/13 22:00 | Jacksonville State v Lamar | W | 38-7 |
| NCAAF | 2021/11/06 18:00 | Abilene Christian v Jacksonville State | W | 25-40 |
| NCAAF | 2021/10/30 18:00 | Central Arkansas v Jacksonville State | L | 38-14 |
| NCAAF | 2021/10/23 19:00 | Jacksonville State v Sam Houston State | L | 7-42 |
| NCAAF | 2021/10/09 20:00 | Stephen F. Austin v Jacksonville State | W | 24-28 |
| NCAAF | 2021/10/02 19:00 | Jacksonville State v Kennesaw State | L | 6-31 |
| NCAAF | 2021/09/25 20:00 | Tennessee Martin v Jacksonville State | L | 34-31 |