DePaul 62-55 Louisville 2021-12-11 01:00
Stadium: KFC Yum! Center
Home Manager: Chris Mack Away Manager: Tony Stubblefield
Head to Head
| NCAAB | 2012/02/18 12:00 | DePaul v Louisville | L | 82-90 |
| NCAAB | 2012/01/14 12:00 | Louisville v DePaul | L | 76-59 |
| NCAAB | 2011/02/05 12:00 | Louisville v DePaul | L | 61-57 |
| NCAAB | 2010/02/20 12:00 | DePaul v Louisville | L | 59-68 |
| NCAAB | 2009/02/15 12:00 | Louisville v DePaul | L | 99-54 |
| NCAAB | 2008/02/12 12:00 | DePaul v Louisville | L | 68-88 |
| NCAAB | 2007/01/20 12:00 | DePaul v Louisville | L | 50-59 |
| NCAAB | 2006/02/22 12:00 | Louisville v DePaul | L | 65-53 |
Home History
| NCAAB | 2021/12/08 01:30 | Duquesne v DePaul | W | 67-87 |
| NCAAB | 2021/12/04 21:00 | Loyola Chicago v DePaul | L | 68-64 |
| NCAAB | 2021/11/28 19:00 | Eastern Michigan v DePaul | W | 63-101 |
| NCAAB | 2021/11/26 22:00 | Northern Kentucky v DePaul | W | 68-77 |
| NCAAB | 2021/11/21 01:00 | Western Illinois v DePaul | W | 80-84 |
| NCAAB | 2021/11/19 01:30 | Rutgers v DePaul | W | 70-73 |
| NCAAB | 2021/11/13 23:00 | Central Michigan v DePaul | W | 66-99 |
| NCAAB | 2021/11/11 02:00 | Coppin State v DePaul | W | 72-97 |
Away History
| NCAAB | 2021/12/04 19:00 | Louisville v NC State | W | 73-68 |
| NCAAB | 2021/12/02 00:15 | Louisville v Michigan State | L | 64-73 |
| NCAAB | 2021/11/27 15:00 | Maryland v Louisville | W | 55-63 |
| NCAAB | 2021/11/26 02:30 | Louisville v Mississippi State | W | 72-58 |
| NCAAB | 2021/11/20 19:00 | Detroit v Louisville | W | 67-73 |
| NCAAB | 2021/11/16 01:00 | Navy v Louisville | W | 60-77 |
| NCAAB | 2021/11/13 00:00 | Furman v Louisville | L | 80-72 |
| NCAAB | 2021/11/10 03:00 | Southern v Louisville | W | 60-72 |
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