USA MLS Next Pro League

On June 21, 2021, Major League Soccer announced the creation of a new professional league which would begin play in 2022. MLS has applied to the United States Soccer Federation for the league to be sanctioned as a Division III professional league, the same level currently occupied by USL League One and the National Independent Soccer Association and one level below the USL Championship. MLS announced that Next Pro would start with at least 20 teams, many of them owned by Major League Soccer and development teams between their first-teams and their youth academies. All MLS clubs with reserve teams in the USL Championship or USL League One initially planned to move those sides to MLS Next Pro by 2023. D.C. United's formerly owned-and-operated reserve team was sold to independent buyers.

The inaugural match of MLS Next Pro was played on March 25, 2022, at Hermann Stadium in St. Louis. St. Louis City SC 2 defeated Rochester New York FC 2–0. Wan Kuzain scored the first ever goal in the 20th minute.

The league makes use of unique rules such as all regular season draws being decided by penalty shootouts and the addition of concussion substitutions. On July 6, 2022, new rules for the league were introduced in the middle of the season. This included an off-field treatment rule meant to curb gamesmanship and timewasting and a new rule for red card suspensions: The suspension a player gets for getting a red card or two yellow cards in the same game will be served by the player when next playing against the same opponent.