Stadium: Spec Martin Stadium Round: 1
Home Manager: Brian Young Away Manager: Steve Englehart
| NCAAF | 2021/10/30 17:00 | Stetson Hatters v Presbyterian | L | 56-14 |
| NCAAF | 2021/04/03 17:00 | Presbyterian v Stetson Hatters | W | 26-3 |
| NCAAF | 2022/11/05 17:00 | Dayton v Presbyterian | L | 52-28 |
| NCAAF | 2022/10/29 16:00 | Presbyterian v Marist | L | 7-37 |
| NCAAF | 2022/10/22 17:00 | St.Thomas MIN v Presbyterian | L | 46-17 |
| NCAAF | 2022/10/15 21:00 | Presbyterian v San Diego | L | 3-28 |
| NCAAF | 2022/10/08 16:00 | Valparaiso v Presbyterian | L | 41-21 |
| NCAAF | 2022/10/01 17:00 | Presbyterian v Morehead State | L | 10-14 |
| NCAAF | 2022/09/24 23:00 | Davidson Wildcats v Presbyterian | L | 56-24 |
| NCAAF | 2022/09/17 19:30 | Presbyterian v Western Carolina | L | 21-77 |
| NCAAF | 2022/11/12 18:00 | Stetson Hatters v St.Thomas MIN | L | 0-23 |
| NCAAF | 2022/11/05 17:00 | Stetson Hatters v Davidson Wildcats | L | 48-56 |
| NCAAF | 2022/10/29 17:00 | Drake Bulldogs v Stetson Hatters | L | 24-17 |
| NCAAF | 2022/10/22 17:00 | Stetson Hatters v Dayton | L | 20-23 |
| NCAAF | 2022/10/08 17:00 | Marist v Stetson Hatters | L | 45-31 |
| NCAAF | 2022/09/24 17:00 | Morehead State v Stetson Hatters | W | 26-38 |
| NCAAF | 2022/09/17 17:00 | Princeton v Stetson Hatters | L | 39-14 |
| NCAAF | 2022/09/10 22:00 | Stetson Hatters v Louisiana College Wildcats | W | 45-14 |