Stadium: William H. Greene Stadium Round: 1
Home Manager: Larry Scott Away Manager: Rod Milstead
| NCAAF | 2021/10/30 18:00 | Howard v Delaware State | W | 23-30 |
| NCAAF | 2021/04/03 17:00 | Delaware State v Howard | W | 37-28 |
| NCAAF | 2021/02/27 17:00 | Howard v Delaware State | W | 10-17 |
| NCAAF | 2019/09/21 18:00 | Howard v Delaware State | L | 24-9 |
| NCAAF | 2018/10/13 17:00 | Delaware State v Howard | L | 13-55 |
| NCAAF | 2017/10/14 18:00 | Delaware State v Howard | L | 23-52 |
| NCAAF | 2022/10/15 18:00 | Delaware State v Norfolk State | W | 28-7 |
| NCAAF | 2022/10/01 22:00 | Robert Morris v Delaware State | W | 9-14 |
| NCAAF | 2022/09/24 18:00 | Merrimack v Delaware State | L | 26-13 |
| NCAAF | 2022/09/17 18:00 | Delaware State v Lynchburg Dragons | W | 35-19 |
| NCAAF | 2022/09/10 22:00 | Delaware State v Delaware | L | 9-35 |
| NCAAF | 2022/09/03 18:00 | Delaware State v Lincoln University Lions | W | 34-0 |
| NCAAF | 2021/11/20 19:00 | Delaware State v North Carolina Central | L | 28-34 |
| NCAAF | 2021/11/13 18:00 | Norfolk State v Delaware State | W | 26-28 |
| NCAAF | 2022/10/15 20:00 | Harvard v Howard | L | 41-25 |
| NCAAF | 2022/10/01 16:00 | Howard v Yale | L | 26-34 |
| NCAAF | 2022/09/17 19:00 | Howard v Morehouse College Maroon Tigers | W | 31-0 |
| NCAAF | 2022/09/10 23:00 | Howard v South Florida | L | 20-42 |
| NCAAF | 2022/09/03 22:00 | Howard v Hampton | L | 28-31 |
| NCAAF | 2021/11/13 18:00 | North Carolina Central v Howard | L | 45-27 |
| NCAAF | 2021/11/06 18:00 | Howard v South Carolina State | L | 12-15 |
| NCAAF | 2021/10/30 18:00 | Howard v Delaware State | L | 23-30 |