Stadium: Arnold D. Stambaugh Stadium Round: 1
Home Manager: Doug Phillips Away Manager: Jerry Schmitt
| NCAAF | 2022/08/27 22:30 | Duquesne v Florida State | L | 7-47 |
| NCAAF | 2021/11/20 17:00 | Duquesne v Wagner | W | 44-0 |
| NCAAF | 2021/11/13 17:00 | Central Connecticut v Duquesne | W | 27-31 |
| NCAAF | 2021/11/06 16:00 | Duquesne v LIU Brooklyn | W | 34-28 |
| NCAAF | 2021/10/30 19:00 | St.Francis (PA) v Duquesne | L | 17-10 |
| NCAAF | 2021/10/23 16:00 | Duquesne v Sacred Heart | L | 13-31 |
| NCAAF | 2021/10/09 16:00 | Bryant v Duquesne | W | 34-39 |
| NCAAF | 2021/10/02 17:00 | Duquesne v Merrimack | W | 37-14 |
| NCAAF | 2021/11/20 18:00 | Youngstown State v SO Illinois | W | 35-18 |
| NCAAF | 2021/11/13 17:00 | North Dakota State v Youngstown State | L | 49-17 |
| NCAAF | 2021/11/06 17:00 | Youngstown State v North Dakota | L | 21-24 |
| NCAAF | 2021/10/30 18:00 | South Dakota State v Youngstown State | L | 47-16 |
| NCAAF | 2021/10/23 17:00 | Youngstown State v Indiana State | L | 17-28 |
| NCAAF | 2021/10/09 18:00 | Missouri St v Youngstown State | W | 33-41 |
| NCAAF | 2021/10/02 21:00 | Youngstown State v Northern Iowa | L | 7-34 |
| NCAAF | 2021/09/25 22:00 | Western Illinois v Youngstown State | L | 38-35 |