Stadium: Buccaneer Field Round: 1
Home Manager: Autry Denson Away Manager: Tre Lamb
| NCAAF | 2021/11/13 18:30 | Charleston Southern v Gardner Webb | L | 32-24 |
| NCAAF | 2021/04/17 16:00 | Gardner Webb v Charleston Southern | L | 7-20 |
| NCAAF | 2019/11/02 17:30 | Charleston Southern v Gardner Webb | L | 30-27 |
| NCAAF FCS | 2018/11/10 20:00 | Gardner Webb v Charleston Southern | L | 0-16 |
| NCAAF | 2017/11/04 17:30 | Gardner Webb v Charleston Southern | L | 9-10 |
| NCAAF | 2022/10/15 19:30 | Gardner Webb v Libertay | L | 20-21 |
| NCAAF | 2022/10/08 16:00 | Gardner Webb v Robert Morris | W | 48-0 |
| NCAAF | 2022/10/01 19:30 | Gardner Webb v Marshall | L | 7-28 |
| NCAAF | 2022/09/24 22:00 | Mercer v Gardner Webb | L | 45-14 |
| NCAAF | 2022/09/17 22:00 | Gardner Webb v Elon | L | 24-30 |
| NCAAF | 2022/09/10 22:00 | Gardner Webb v Coastal Carolina | L | 27-31 |
| NCAAF | 2022/09/01 23:00 | Gardner Webb v Limestone Saints | W | 56-21 |
| NCAAF | 2021/11/20 18:00 | Gardner Webb v North Carolina A&T | W | 35-27 |
| NCAAF | 2022/10/15 20:00 | Charleston Southern v Bryant | W | 24-23 |
| NCAAF | 2022/10/08 20:00 | Charleston Southern v Campbell | L | 28-34 |
| NCAAF | 2022/09/24 16:00 | Furman v Charleston Southern | L | 24-19 |
| NCAAF | 2022/09/17 22:00 | Charleston Southern v Eastern Kentucky | L | 17-40 |
| NCAAF | 2022/09/10 16:30 | Charleston Southern v NC State | L | 3-55 |
| NCAAF | 2022/09/03 16:00 | Western Carolina v Charleston Southern | L | 52-38 |
| NCAAF | 2021/11/20 17:00 | Charleston Southern v Georgia | L | 7-56 |
| NCAAF | 2021/11/13 18:30 | Charleston Southern v Gardner Webb | W | 32-24 |