Stadium: O'Brien Stadium Round: 1
Home Manager: Adam Cushing Away Manager:
| NCAAF | 2021/03/14 18:00 | Eastern Illinois v Tennessee State | W | 20-21 |
| NCAAF | 2019/11/09 20:00 | Eastern Illinois v Tennessee State | L | 49-38 |
| NCAAF | 2018/09/22 19:00 | Tennessee State v Eastern Illinois | W | 41-40 |
| NCAAF | 2017/09/30 23:00 | Tennessee State v Eastern Illinois | L | 16-19 |
| NCAAF | 2021/10/16 19:00 | Tennessee Tech v Tennessee State | W | 13-20 |
| NCAAF | 2021/10/03 00:00 | Tennessee State v Austin Peay | W | 24-22 |
| NCAAF | 2021/09/25 19:00 | Tennessee State v SE Missouri St | L | 14-47 |
| NCAAF | 2021/09/18 19:00 | Tennessee State v Kentucky Thorobreds | W | 41-7 |
| NCAAF | 2021/09/11 23:00 | Jackson State v Tennessee State | L | 38-16 |
| NCAAF | 2021/09/05 20:00 | Grambling State v Tennessee State | L | 16-10 |
| NCAAF | 2021/04/11 19:30 | SE Missouri St v Tennessee State | L | 46-23 |
| NCAAF | 2021/04/03 18:30 | Tennessee State v Tennessee Tech | L | 10-24 |
| NCAAF | 2021/10/16 19:00 | Tennessee Martin v Eastern Illinois | L | 28-17 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | L | 6-22 |
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | W | 28-14 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | L | 31-24 |
| NCAAF | 2021/09/11 17:00 | Eastern Illinois v Dayton | L | 10-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | L | 0-46 |
| NCAAF | 2021/08/28 22:00 | Eastern Illinois v Indiana State | L | 21-26 |
| NCAAF | 2021/04/03 18:00 | Jacksonville State v Eastern Illinois | L | 44-23 |