Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Bob Nielson
| NCAAF FCS | 2018/11/10 19:00 | Western Illinois v South Dakota | W | 12-17 |
| NCAAF FCS | 2018/11/03 17:00 | South Dakota v Indiana State | L | 48-51 |
| NCAAF | 2018/10/27 19:00 | South Dakota v North Dakota State | L | 14-59 |
| NCAAF | 2018/10/20 22:00 | Youngstown State v South Dakota | L | 29-17 |
| NCAAF | 2018/10/13 23:00 | Northern Iowa v South Dakota | L | 42-28 |
| NCAAF | 2018/10/06 19:00 | Missouri St v South Dakota | W | 28-35 |
| NCAAF | 2018/09/29 23:00 | South Dakota v SO Illinois | W | 31-24 |
| NCAAF | 2018/09/16 00:00 | South Dakota v Weber State | L | 10-27 |
| NCAAF FCS | 2018/11/10 19:00 | South Dakota State v SO Illinois | W | 57-38 |
| NCAAF FCS | 2018/11/03 19:00 | Missouri St v South Dakota State | W | 7-59 |
| NCAAF | 2018/10/27 17:00 | Illinois State v South Dakota State | W | 28-38 |
| NCAAF | 2018/10/20 21:00 | Northern Iowa v South Dakota State | L | 24-9 |
| NCAAF | 2018/10/13 19:00 | Youngstown State v South Dakota State | W | 7-36 |
| NCAAF | 2018/10/06 23:00 | Indiana State v South Dakota State | W | 51-54 |
| NCAAF | 2018/09/29 19:30 | South Dakota State v North Dakota State | L | 17-21 |
| NCAAF | 2018/09/15 23:00 | South Dakota State v Arkansas Pine Bluff | W | 90-6 |